CANDIDA PATÓGENA BUCAL EN PACIENTES BAJO TERAPIAS ANTINEOPLÁSICAS

MARTHA LEONOR REBOLLEDO COBOS

Resumen


Los tratamientos para el control del cáncer están encaminados a prolongar la sobrevida del paciente, pero al mismo tiempo desencadenan efectos inevitables e irreversibles, así como infecciosos, los cuales complican el pronóstico de la enfermedad oncológica. Dentro de estos últimos se encuentra la conducta patógena de Candida, cuya especie más común en la mucosa oral es albicans, considerada un hongo comensal que, a consecuencia de la neutropenia resultante de las terapias antineoplásicas, se comporta como oportunista y causa candidiasis. Esta infección fúngica tiene factores agravantes e inherentes al paciente, como la xerostomía y la hiposalivación, infecciones como la caries dental, y otros factores como la incorrecta higiene bucal. Diversos autores consultados resaltan la presencia de Candida, sus diferentes especies y la candidiasis bucal como microorganismo e infección clásica oportunista en pacientes inmunosuprimidos, y aún más en aquellos sometidos a tratamientos antineoplásicos. El objetivo de la presente revisión consiste en describir el comportamiento patógeno de Candida en la mucosa bucal de pacientes bajo tratamientos antineoplásicos.


Texto completo:

PDF (English)

Referencias


Teoh F, Pavelka N. How Chemotherapy Increases the Risk of Systemic Candidiasis in Cancer Patients: Current Paradigm and Future Directions. Pathogens. 2016;15;5(1).

Rodríguez-Leguizamón G, Fiori A, López LF; et al. Characterising atypical Candida albicans clinical isolates from six third-level hospitals in Bogotá, Colombia. BMC Microbiol. 2015;15(1):199.

Villanueva Reyes J, Arenas R, Candidiasis mucocutánea. Una revisión. Rev Mex Micol. 2007;25:91-104.

De Sousa LV, Santos VL, de Souza Monteiro A; et al. Isolation and identification of Candida species in patients with orogastric cancer: susceptibility to antifungal drugs, attributes of virulence in vitro and immune response phenotype. BMC Infect Dis. 2016;23;16(1):86.

Yamashita K, Ohara M, Kojima T; et al. Prevalence of drug-resistant opportunistic microorganisms in oral cavity after treatment for oral cancer. J Oral Sci. 2013;55(2):145-55.

Komeno Y, Uryu H, Iwata Y, Hatada Y, Sakamoto J, Iihara K, Ryu T. Esophageal Candidiasis as the Initial Manifestation of Acute Myeloid Leukemia. Intern Med. 2015;54(23):3087-92.

Alt-Epping B, Nejad RK, Jung K, Gross U, Nauck F. Symptoms of the oral cavity and their association with local microbiological and clinical findings--a prospective survey in palliative care. Support Care Cancer. 2012;20(3):531-7.

Singh A, Verma R, Murari A, Agrawal A. Oral candidiasis: An overview. J Oral Maxillofac Pathol. 2014;18(1):S81-5.

MoralesCA, Sánchez G. Candidiasis mucocutánea: espectro clínico. Rev Asoc Colomb Dermatol. 2011;19: 239-244.

Del Palacio A., Villar J. y Alhambra A. Epidemiología de las candidiasis invasoras en población pediátrica y adulta. Rev Iberoam Micol. 2009; 26(1):2-7.

Patil S, Rao RS, Majumdar B, Anil S. Clinical Appearance of Oral Candida Infection and Therapeutic Strategies. Front Microbiol. 2015:17; 6:1391.

Kakati B, Kotwal A, Biswas D, Sahu S. Fluconazole Resistant Candida Oesophagitis in Immunocompetent Patients: Is Empirical Therapy Justifiable? J Clin Diagn Res. 2015;9(12):DC16-8.

Prieto D, Pla J. Distinct stages during colonization of the mouse gastrointestinal tract by Candida albicans. Front Microbiol. 2015;5; 6:792.

Jung DS, Farmakiotis D, Jiang Y, Tarrand JJ, Kontoyiannis DP. Uncommon Candida Species Fungemia among Cancer Patients, Houston, Texas, USA. Emerg Infect Dis. 2015;21(11):1942-50.

Lim S, Kil TJ, Kim HR, Han S, Rha SY. A case of gingival candidiasis with bone destruction on gastric cancer patient receiving cytotoxic chemotherapy. ase Rep Oncol Med. 2014; 2014:145394.

Xu L, Zhang H, Liu J, Chen X. Investigation of the oral infections and manifestations seen in patients with advanced cancer. Pak J Med Sci. 2013;29(5):1112-5.

Gall F, Colella G, Di Onofrio V, Rossiello R, Angelillo IF, Liguori G. Candida spp. in oral cancer and oral precancerous lesions. New Microbiol. 2013;36(3):283-8.

Shrestha M, Boaz K, Srikant N, Shakya A. An assessment of candidal colonization and species differentiation in head and neck cancer patients receiving radiation. J Nepal Health Res Counc. 2014;12(28):156-61.

Modrzewska B, Kurnatowski P. Adherence of Candida sp. to host tissues and cells as one of its pathogenicity features. Ann Parasitol. 2015;61(1):3-9.

Galipothu S, Kalawat U, Ram R, Kishore C, Sridhar AV, Chaudhury A, Kumar VS. Cutaneous fungal infection in a renal transplantation patient due to a rare fungus belonging to order Pleosporales. Indian J Med Microbiol. 2015;33(1):165-7.

Chambô Filho A, Souza Filho JB, Pignaton CC, Zon I, Fernandes AS, Cardoso LQ. Chronic mucocutaneous candidiasis: a case with exuberant cutaneous horns in nipples. An Bras Dermatol. 2014;89(4):641-4.

Hirakawa MP, Martinez DA, Sakthikumar S; et al. Genetic and phenotypic intra-species variation in Candida albicans. Abstract Send to: Genome Res. 2015;25(3):413-25.

Raz-Pasteur A, Ullmann Y, Berdicevsky I. The pathogenesis of Candida infections in a human skin model: scanning electron microscope observations. SRN Dermatol. 2011; 2011:150642.

Laronde DM, Williams PM, Hislop TG; et al. Decision making on detection and triage of oral mucosa lesions in community dental practices: screening decisions and referral. Community Dent Oral Epidemiol. 2014;42(4):375-84.

Roberts CL, Algert CS, Rickard KL; et al. Treatment of vaginal candidiasis for the prevention of preterm birth: a systematic review and meta-analysis. Syst Rev. 2015;21; 4:31.

Balan P, B Gogineni S, Kumari N S; et al. Candida Carriage Rate and Growth Characteristics of Saliva in Diabetes Mellitus Patients: A Case-Control Study. J Dent Res Dent Clin Dent Prospects. 2015;9(4):274-9.

Kok ET, Jong MC, Gravendeel B, Van Leeuwen WB, Baars EW. Resistance to Antibiotics and Antifungal Medicinal Products: Can Complementary and Alternative Medicine Help Solve the Problem in Common Infection Diseases? The Introduction of a Dutch Research Consortium. Evid Based Complement Alternat Med. 2015;2015:521584.

Komeno Y, Uryu H, Iwata Y, Hatada Y, Sakamoto J, Iihara K, Ryu T. Esophageal Candidiasis as the Initial Manifestation of Acute Myeloid Leukemia. Intern Med. 2015;54(23):3087-92.

Meighani G1, Aghamohammadi A, Javanbakht H; et al. Oral and dental health status in patients with primary antibody deficiencies. Iran J Allergy Asthma Immunol. 2011;10(4):289-93.

Teoh F, Pavelka N. How Chemotherapy Increases the Risk of Systemic Candidiasis in Cancer Patients: Current Paradigm and Future Directions. Pathogens. 2016;15;5(1).

Lara HH, Romero-Urbina DG, Pierce C, Lopez-Ribot JL, Arellano-Jiménez MJ, Jose-Yacaman M. Effect of silver nanoparticles on Candida albicans biofilms: an ultrastructural study. J Nanobiotechnology. 2015;15;13:91.

Akbari F, Kjellerup BV. Elimination of Bloodstream Infections Associated with Candida albicans Biofilm in Intravascular Catheters. Pathogens. 2015;4(3):457-69.

De Paula SB, Morey AT, Santos JP, Dos Santos PM; et al. Oral Candida colonization in HIV-infected patients in Londrina-PR, Brazil: antifungal susceptibility and virulence factors. J Infect Dev Ctries. 2015;9(12):1350-9.

Popova EV, Dermendjieva SI, Vangelova RP. Quantity determination of T- and B-leucocytes in peripheral blood in patients with candida induced subprosthetic stomatitis. Folia Med (Plovdiv). 2001;43(1-2):50-2.

Garcia-Cuesta C, Sarrion-Pérez MG, Bagán JV. Current treatment of oral candidiasis: A literature review. J Clin Exp Dent. 2014:1;6(5):e576-82.

Thomson DD, Berman J, Brand AC. High frame-rate resolution of cell division during Candida albicans filamentation. Fungal Genet Biol. 2016; 88:54-8.

Kok ET, Jong MC, Gravendeel B, Van Leeuwen WB, Baars EW. Resistance to Antibiotics and Antifungal Medicinal Products: Can Complementary and Alternative Medicine Help Solve the Problem in Common Infection Diseases? The Introduction of a Dutch Research Consortium. Evid Based Complement Alternat Med. 2015;2015:521-584.

Rabagliati R, Fuentes G, Guzmán AM, Orellana E, Oporto J, Aedo I, y cols. Enfermedad fúngica invasora en pacientes hemato-oncológicos y receptores de trasplante de precursores hematopoyéticos bajo la perspectiva de los criterios diagnósticos EORTC/MSG. Rev Chil Infect 2009; 26 (3): 212-219

Puig-Asensio M, Ruiz-Camps I, Fernández-Ruiz M; et al. Epidemiology and outcome of candidaemia in patients with oncological and haematological malignancies: results from a population-based surveillance in Spain. Clin Microbiol Infect. 2015;21(5):491.e1-10.

Shrestha M, Boaz K, Srikant N, Shakya A. An assessment of candidal colonization and species differentiation in head and neck cancer patients receiving radiation. J Nepal Health Res Counc. 2014;12(28):156-61.

Krishnan PA. Fungal infections of the oral mucosa. Indian J Dent Res. 2012;23(5):650-9.

Verma SP, Dubashi B, Narayanan P, Basu D, Dutta TK, Dhanraj KM. A case of pediatric acute lymphoblastic leukemia with invasive candidiasis: short review. Indian J Hematol Blood Transfus. 2014;30(1):101-4.

Morais EF, Lira JA, Macedo RA, Santos KS, Elias CT, Morais Mde L. Oral manifestations resulting from chemotherapy in children with acute lymphoblastic leukemia. Braz J Otorhinolaryngol. 2014;80(1):78-85.

Ramla S, Sharma V, Patel M. Influence of cancer treatment on the Candida albicans isolated from the oral cavities of cancer patients. Support Care Cancer. 2016;24(6):2429-36.

Ueta E, Tanida T, Yoneda K, Yamamoto T, Osaki T. Increase of Candida cell virulence by anticancer drugs and irradiation. Oral Microbiol Immunol. 2001;16(4):243-9.

van Burik J A, Ratanatharathorn V, Stepan D E, Miller C B, Lipton J H, Vesole D H, et al. Micafungin versus fluconazole for prophylaxis against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantation. Clin Infec Dis 2004; 39: 1407-16. 41.

Cornely O A, Maertens J, Winston D J, Perfect J, Ullman A J, Walsh T J, et al. Posaconazole vs fluconazole or itraconazole prophylaxis in patients with neutropenia. N Engl J Med 2007; 356: 348-59. 42

Siwek G T, Dodgson K J, de MagalhaesSilverman M, Bartelt L A, Kilborn S B, Hoth P L, et al. Invasive zygomycosis in hematopoietic stem cell transplant recipients receiving voriconazole prophylaxis. Clin Infect Dis 2004; 39: 584-7. 44.

Pizzo P A, Robichaud K J, Gill F A, Witebsky F G. Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia. Am J Med 1982; 72: 101-11.

Pemán J, Zaragoza R, Quindós G, Alkorta M, Cuétara MS, Camarena JJ, et al. Clinical factors associated with a Candida albicans Germ Tube Antibody positive test in Intensive Care Unit patients. Infect Dis. 2011;9;11:60

Li X, Hou Y, Yue L. Potential Targets for Antifungal Drug Discovery Based on Growth and Virulence in Candida albicans. Antimicrob Agents Chemother. 2015;59(10):5885-91.

Tosun I, Aydin F, Kaklikkaya N, Erturk M. Induction of secretory aspartyl proteinase of Candida albicans by HIV-1 but not HSV-2 or some other microorganisms associated with vaginal environment. Mycopathol. 2005;159(2):213-8.

Konopka T, Dembowska E, Pietruska M, Dymalski P, Górska R. Periodontal status and selected parameters of oral condition of Poles aged 65 to 74 years. Przegl Epidemiol. 2015;69(3):537-42, 643-7.

Alt-Epping B, Nejad RK, Jung K, Gross U, Nauck F. Symptoms of the oral cavity and their association with local microbiological and clinical findings--a prospective survey in palliative care. Support Care Cancer. 2012;20(3):531-7.

Ramage G, Vandewalle K, Wickes BL, López-Ribot JL. Characteristics of biofilm formation by Candida albicans. Rev Iberoam Micol. 2001;18(4):163-70.

Carmona M., Pulido M; et al. Presencia de cándida en pacientes con estomatitis subprotesica que acuden a la facultad de odontología de la universidad de Cartagena en el periodo transcurrido entre agosto 2006 - junio 2007. Duazary. 2008;5(2):90-98.

Rebolledo M, Pastor M. Comportamiento de prótesis dentales removibles como factor causal de estomatitis sub-protésica: Reporte de un caso. Act odont Col. 2012;2(2):105-111.




DOI: https://doi.org/10.17533/udea.rfo.v30n1a9 Resumen : 109 PDF (English) : 92

Métricas de artículo

Cargando métricas ...

Metrics powered by PLOS ALM


Esta publicación hace parte del Sistema de Revistas de la Universidad de Antioquia
¿Quieres aprender a usar el Open Journal system? Ingresa al Curso virtual
Este sistema es administrado por el Programa Integración de Tecnologías a la Docencia
Universidad de Antioquia
Powered by Public Knowledge Project