Rubiel Antonio Marín Jaramillo, Alejandro Villegas Giraldo, Andrés Duque Duque, Astrid Giraldo Aristizabal, Viviana Muñoz Giraldo


Introduction: the incidence of peri-implant diseases is high, and their optimal management is still debated. The purpose was to explore the levels of available evidence and to suggest evidence-based recommendations for the treatment of peri-implant mucositis and peri-implantitis. Methods: a clinical practice guideline was developed using the Scottish Intercollegiate Guidelines Network (SIGN) criteria. A search strategy was formulated, and a critical review of the following evidence was performed: 1) prevention of peri-implant diseases, 2) treatment of peri-implant mucositis, and 3) treatment of peri-implantitis. Systematic reviews and randomized controlled clinical trials were the primary study types identified in the literature. Current levels of evidence were established and recommendations were provided. Results: a total of 67 articles were included. Regarding the prevention of peri-implant diseases, there is strong evidence for the involvement of patients in a regular maintenance program according to their risk profile. Regarding the treatment of peri-implant mucositis, infection control measures are recommended; controversy exists over the usefulness of antimicrobial agents, and there is evidence against the use of antibiotics. Selection of the peri-implantitis treatment method depends on the severity of the condition and patient-related factors. Resective and regenerative therapies may be used
for treatment. The use of systemic antibiotics favors the response of clinical parameters. There is conditional evidence for the use of other adjunctive therapies. Conclusions: the best way to prevent peri-implantitis is to prevent peri-implant mucositis through adherence to supportive periodontal therapy. Treatment of peri-implant diseases depends on local and systemic conditions that affect the success of other treatment options.

Full Text:



Lang NP, Zitzmann NU. Clinical research in implant dentistry: evaluation of implant-supported restorations, aesthetic and patient-reported outcomes. J Clin Periodontol. 2012; 39(Suppl 12): 133-8. DOI: https://doi.org/10.1111/j.1600-051X.2011.01842.x

Lang NP, Pun L, Lau KY, Li KY, Wong MCM. A systematic review on survival and success rates of implants placed immediately into fresh extraction sockets after at least 1 year. Clin Oral Implants Res. 2012; 23(Suppl 5): 39-66. DOI: https://doi.org/10.1111/j.1600-0501.2011.02372.x

Sousa V, Mardas N, Farias B, Petrie A, Needleman I, Spratt D, et al. A systematic review of implant outcomes in treated periodontitis patients. Clin Oral Implants Res. 2016; 27(7): 787-844. DOI: https://doi.org/10.1111/clr.12684

Smith Nobrega A, Santiago JF Jr, de Faria Almeida DA, Dos Santos DM, Pellizzer EP, Goiato MC. Irradiated patients and survival rate of dental implants: A systematic review and meta-analysis. J Prosthet Dent. 2016; 116(6): 858-66. DOI: https://doi.org/10.1016/j.prosdent.2016.04.025

Srinivasan M, Meyer S, Mombelli A, Müller F. Dental implants in the elderly population: a systematic review and meta-analysis. Clin Oral Implants Res. 2016; 28(8): 920-30. DOI: https://doi.org/10.1111/clr.12898

Moraschini V, Barboza Ed. Success of dental implants in smokers and non-smokers: a systematic review and meta-analysis. Int J Oral Maxillofac Surg. 2016; 45(2): 205-15. DOI: https://doi.org/10.1016/j.ijom.2015.08.996

Thoma DS, Zeltner M, Hüsler J, Hämmerle CH, Jung RE. EAO Supplement Working Group 4 - EAO CC 2015 Short implants versus sinus lifting with longer implants to restore the posterior maxilla: a systematic review. Clin Oral Implants Res. 2015; 26 (Suppl 11): 154-69. DOI: https://doi.org/10.1111/clr.12615

Zangrando MS, Damante CA, Sant’Ana AC, Rubo de Rezende ML, Greghi SL, Chambrone L. Long-term evaluation of periodontal parameters and implant outcomes in periodontally compromised patients: a systematic review. J Periodontol. 2015; 86(2): 201-21. DOI: https://doi.org/10.1902/jop.2014.140390

Lang NP, Berglundh T. Periimplant diseases: where are we now? Consensus of the Seventh European Workshop on Periodontology. J Clin Periodontol. 2011; 38(Suppl 11): 178-81. DOI: https://doi.org/10.1111/j.1600-051X.2010.01674.x

Heitz-Mayfield LJA. Peri-implant diseases: diagnosis and risk indicators. J Clin Periodontol. 2008; 35(8 Suppl): 292-304. DOI: https://doi.org/10.1111/j.1600-051X.2008.01275.x

Albouy JP, Abrahamsson I, Berglundh T. Spontaneous progression of experimental peri-implantitis at implants with different surface characteristics: an experimental study in dogs. J Clin Periodontol. 2012; 39(2): 182-7. DOI: https://doi.org/10.1111/j.1600-051X.2011.01820.x

Duque AD, Aristizabal AG, Londoño S, Castro L, Alvarez LG. Prevalence of peri-implant disease on platform switching implants: a cross-sectional pilot study. Braz Oral Res. 2016; 30. DOI: https://doi.org/10.1590/1807-3107BOR-2016.vol30.0005

Mouhyi J, Dohan Ehrenfest DM, Albrektsson T. The peri-implantitis: implant surfaces, microstructure, and physicochemical aspects. Clin Implant Dent Relat Res. 2012; 14(2): 170-83. DOI: https://doi.org/10.1111/


Papaspyridakos P, Chen CJ, Chuang SK, Weber HP, Gallucci GO. A systematic review of biologic and technical complications with fixed implant rehabilitations for edentulous patients. Int J Oral Maxillofac Implants. 2012; 27(1): 102-10.

Naert I, Duyck J, Vandamme K. Occlusal overload and bone/implant loss. Clin Oral Implants Res. 2012; 23(suppl 6): 95-107. DOI: https://doi.org/10.1111/j.1600-0501.2012.02550.x

Turri A, Rossetti PHO, Canullo L, Grusovin MG, Dahlin C. Prevalence of Peri-implantitis in Medically Compromised Patients and Smokers: A Systematic Review. Int J Oral Maxillofac Implants. 2016; 31(1):111-8. DOI: https://doi.org/10.11607/jomi.4149

Monje A, Alcoforado G, Padial-Molina M, Suarez F, Lin GH, Wang HL. Generalized aggressive periodontitis as a risk factor for dental implant failure: a systematic review and meta-analysis. J Periodontol. 2014; 85(10): 1398-407. DOI: https://doi.org/10.1902/jop.2014.140135

Sgolastra F, Petrucci A, Severino M, Gatto R, Monaco A. Periodontitis, implant loss and peri-implantitis. A meta-analysis. Clin Oral Implants Res. 2015; 26(4): e8-16. DOI: https://doi.org/10.1111/clr.12319

Sgolastra F, Petrucci A, Severino M, Gatto R, Monaco A. Smoking and the risk of peri-implantitis. A systematic review and meta-analysis. Clin Oral Implants Res. 2015; 26(4): e62-7. DOI: https://doi.org/10.1111/clr.12333

Hamdy AA-MM, Ebrahem MA. The effect of interleukin-1 allele 2 genotype (IL-1a(-889) and IL-1b(+3954)) on the individual’s susceptibility to peri-implantitis: case-control study. J Oral Implantol. 2011; 37(3): 325-34. DOI: https://doi.org/10.1563/AAID-JOI-D-09-00117.1

Sanz M, Bäumer A, Buduneli N, Dommisch H, Farina R, Kononen E, et al. Effect of professional mechanical plaque removal on secondary prevention of periodontitis and the complications of gingival and periodontal preventive measures: consensus report of group 4 of the 11th European Workshop on Periodontology on effective prevention of periodontal and peri-implant diseases. J Clin Periodontol. 2015; 42(Suppl 16): S214-20. DOI: https://doi.org/10.1111/jcpe.12367

Jepsen S, Berglundh T, Genco R, Aass AM, Demirel K, Derks J, et al. Primary prevention of peri-implantitis: managing peri-implant mucositis. J Clin Periodontol. 2015; 42(Suppl 16): S152-7. DOI: https://doi.org/10.1111/jcpe.12369

Armitage GC, Xenoudi P. Post-treatment supportive care for the natural dentition and dental implants. Periodontol 2000. 2016; 71(1): 164-84. DOI: https://doi.org/10.1111/prd.12122

Monje A, Aranda L, Diaz KT, Alarcón MA, Bagramian RA, Wang HL, et al. Impact of Maintenance Therapy for the Prevention of Peri-implant Diseases: A Systematic Review and Meta-analysis. J Dent Res. 2016; 95(4): 372-9. DOI: https://doi.org/10.1177/0022034515622432

Salvi GE, Ramseier CA. Efficacy of patient-administered mechanical and/or chemical plaque control protocols in the management of peri-implant mucositis. A systematic review. J Clin Periodontol. 2015; 42(Suppl 16): S187-201. DOI: https://doi.org/10.1111/jcpe.12321

Muthukuru M, Zainvi A, Esplugues EO, Flemmig TF. Non-surgical therapy for the management of periimplantitis: a systematic review. Clin Oral Implants Res. 2012; 23 (Suppl 6): 77-83. DOI: https://doi.org/10.1111/j.1600-0501.2012.02542.x

Salvi GE, Zitzmann NU. The effects of anti-infective preventive measures on the occurrence of biologic implant complications and implant loss: a systematic review. Int J Oral Maxillofac Implants. 2014; 29 Suppl: 292-307. DOI: https://doi.org/10.11607/jomi.2014suppl.g5.1

Sculean A, Aoki A, Romanos G, Schwarz F, Miron RJ, Cosgarea R. Is Photodynamic Therapy an Effective Treatment for Periodontal and Peri-Implant Infections? Dent Clin North Am. 2015; 59(4): 831-58. DOI: https://doi.org/10.1016/j.cden.2015.06.008

Schwarz F, Becker K, Renvert S. Efficacy of air polishing for the non-surgical treatment of peri-implant diseases: a systematic review. J Clin Periodontol. 2015; 42(10): 951-9. DOI: https://doi.org/10.1111/jcpe.12454

Natto ZS, Aladmawy M, Levi PA, Wang HL. Comparison of the efficacy of different types of lasers for the treatment of peri-implantitis: a systematic review. Int J Oral Maxillofac Implants. 2015; 30(2): 338-45. DOI: https://doi.org/10.11607/jomi.3846

Khoshkam V, Suárez-López Del Amo F, Monje A, Lin GH, Chan HL, Wang HL. Long-term Radiographic and Clinical Outcomes of Regenerative Approach for Treating Peri-implantitis: A Systematic Review and Metaanalysis. Int J Oral Maxillofac Implants. 2016; 31(6): 1303-10. DOI: https://doi.org/10.11607/jomi.4691

Heitz-Mayfield LJA, Needleman I, Salvi GE, Pjetursson BE. Consensus Statements and Clinical Recommendations for Prevention and Management of Biologic and Technical Implant Complications. Int J Oral Maxillofac Implants. 2014; 29Suppl: 346-50. DOI: https://doi.org/10.11607/jomi.2013.g5

Heitz-Mayfield LJA, Mombelli A. The therapy of peri-implantitis: a systematic review. Int J Oral Maxillofac Implants. 2014; 29(Suppl): 325-45. DOI: https://doi.org/10.11607/jomi.2014suppl.g5.3

Faggion CM, Listl S, Frühauf N, Chang HJ, Tu YK. A systematic review and Bayesian network meta-analysis of randomized clinical trials on non-surgical treatments for peri-implantitis. J Clin Periodontol. 2014; 41(10):1015-25. DOI: https://doi.org/10.1111/jcpe.12292

Chan HL, Lin GH, Suarez F, MacEachern M, Wang HL. Surgical management of peri-implantitis: a systematic review and meta-analysis of treatment outcomes. J Periodontol. 2014; 85(8): 1027-41. DOI: https://doi.org/10.1902/jop.2013.130563

Khoshkam V, Chan HL, Lin GH, MacEachern MP, Monje A, Suarez F, et al. Reconstructive procedures for treating peri-implantitis: a systematic review. J Dent Res. 2013; 92(Suppl 12): S131-8. DOI: https://doi.org/10.1177/0022034513509279

Esposito M, Grusovin MG, Worthington HV. Interventions for replacing missing teeth: treatment of periimplantitis. Cochrane Database Syst Rev. 2012; 1: CD004970. DOI: https://doi.org/10.1002/14651858.CD004970.pub5

Information about SIGN 50 [Internet]. Disponible en: https://www.sign.ac.uk/sign-50.html

Pagliaro U, Nieri M, Rotundo R, Cairo F, Carnevale G, Esposito M, et al. Clinical guidelines of the Italian Society of Periodontology for the reconstructive surgical treatment of angular bony defects in periodontal patients. J Periodontol. 2008; 79(12): 2219-32. DOI: https://doi.org/10.1902/jop.2008.080266

Derks J, Schaller D, Håkansson J, Wennström JL, Tomasi C, Berglundh T. Effectiveness of Implant Therapy Analyzed in a Swedish Population: Prevalence of Peri-implantitis. J Dent Res. 2016; 95(1): 43-9. DOI: https://doi.org/10.1177/0022034515608832

Atieh MA, Alsabeeha NH, Faggion CM, Duncan WJ. The frequency of peri-implant diseases: a systematic review and meta-analysis. J Periodontol. 2013; 84(11): 1586-98. https://doi.org/10.1902/jop.2012.120592

Derks J, Tomasi C. Peri-implant health and disease. A systematic review of current epidemiology. J Clin Periodontol. 2015; 42(Suppl 16): S158-71. DOI: https://doi.org/10.1111/jcpe.12334

Costa FO, Takenaka-Martinez S, Cota LOM, Ferreira SD, Silva GLM, Costa JE. Peri-implant disease in subjects with and without preventive maintenance: a 5-year follow-up. J Clin Periodontol. 2012; 39(2):173-81. DOI: https://doi.org/10.1111/j.1600-051X.2011.01819.x

Tonetti MS, Chapple IL, Jepsen S, Sanz M. Primary and secondary prevention of periodontal and periimplant diseases: Introduction to, and objectives of the 11th European Workshop on Periodontology consensus conference. J Clin Periodontol. 2015; 42(Suppl 16): S1-4. DOI: https://doi.org/10.1111/jcpe.12382

Chrcanovic BR, Albrektsson T, Wennerberg A. Periodontally compromised vs. periodontally healthy patients and dental implants: a systematic review and meta-analysis. J Dent. 2014; 42(12): 1509-27. DOI: https://doi.org/10.1016/j.jdent.2014.09.013

Naujokat H, Kunzendorf B, Wiltfang J. Dental implants and diabetes mellitus-a systematic review. Int J Implant Dent. 2016; 2(1): 5. DOI: https://doi.org/10.1186/s40729-016-0038-2

Salvi GE, Aglietta M, Eick S, Sculean A, Lang NP, Ramseier CA. Reversibility of experimental peri-implant mucositis compared with experimental gingivitis in humans. Clin Oral Implants Res. 2012; 23(2): 182-90. DOI: https://doi.org/10.1111/j.1600-0501.2011.02220.x

Heitz-Mayfield LJA, Lang NP. Comparative biology of chronic and aggressive periodontitis vs. periimplantitis. Periodontol 2000. 2010; 53: 167-81. DOI: https://doi.org/10.1111/j.1600-0757.2010.00348.x

Ericsson I, Berglundh T, Marinello C, Liljenberg B, Lindhe J. Long-standing plaque and gingivitis at implants and teeth in the dog. Clin Oral Implants Res. 1992; 3(3): 99-103. DOI: https://doi.org/10.1034/j.1600-0501.1992.030301.x

Roos-Jansåker AM, Lindahl C, Renvert H, Renvert S. Nine- to fourteen-year follow-up of implant treatment. Part II: presence of peri-implant lesions. J Clin Periodontol. 2006; 33(4): 290-5. DOI: https://doi.org/10.1111/j.1600-051X.2006.00906.x

Rodrigo D, Martin C, Sanz M. Biological complications and peri-implant clinical and radiographic changes at immediately placed dental implants. A prospective 5-year cohort study. Clin Oral Implants Res. 2012; 23(10): 1224-31. DOI: https://doi.org/10.1111/j.1600-0501.2011.02294.x

McKenna DF, Borzabadi-Farahani A, Lynch E. The effect of subgingival ozone and/or hydrogen peroxide on the development of peri-implant mucositis: a double-blind randomized controlled trial. Int J Oral Maxillofac Implants. 2013; 28(6): 1483-9. DOI: https://doi.org/10.1160/jomi.3168

Menezes KM, Fernandes-Costa AN, Silva-Neto RD, Calderon PS, Gurgel BC. Efficacy of 0.12% Chlorhexidine Gluconate for Non-Surgical Treatment of Peri-Implant Mucositis. J Periodontol. 2016; 87(11): 1305-13. DOI: https://doi.org/10.1902/jop.2016.160144

Thöne-Mühling M, Swierkot K, Nonnenmacher C, Mutters R, Flores-de-Jacoby L, Mengel R. Comparison of two full-mouth approaches in the treatment of peri-implant mucositis: a pilot study. Clin Oral Implants Res. 2010; 21(5): 504-12. DOI: https://doi.org/10.1111/j.1600-0501.2009.01861.x

Heitz-Mayfield LJA, Salvi GE, Botticelli D, Mombelli A, Faddy M, Lang NP, et al. Anti-infective treatment of peri-implant mucositis: a randomised controlled clinical trial. Clin Oral Implants Res. 2011; 22(3): 237-41. DOI: https://doi.org/10.1111/j.1600-0501.2010.02078.x

Porras R, Anderson GB, Caffesse R, Narendran S, Trejo PM. Clinical response to 2 different therapeutic regimens to treat peri-implant mucositis. J Periodontol. 2002; 73(10): 1118-25. DOI: https://doi.org/10.1902/jop.2002.73.10.1118

De Siena F, Francetti L, Corbella S, Taschieri S, Del Fabbro M. Topical application of 1% chlorhexidine gel versus 0.2% mouthwash in the treatment of peri-implant mucositis. An observational study. Int J Dent Hyg. 2013; 11(1): 41-7. DOI: https://doi.org/10.1111/idh.12002

Sreenivasan PK, Vered Y, Zini A, Mann J, Kolog H, Steinberg D, et al. A 6-month study of the effects of 0.3% triclosan/copolymer dentifrice on dental implants. J Clin Periodontol. 2011; 38(1): 33-42. DOI: https://doi.org/10.1111/j.1600-051X.2010.01617.x

Hallström H, Persson GR, Lindgren S, Olofsson M, Renvert S. Systemic antibiotics and debridement of peri-implant mucositis. A randomized clinical trial. J Clin Periodontol. 2012; 39(6): 574-81. DOI: https://doi.org/10.1111/j.1600-051X.2012.01884.x

Lee J, Lim JH, Lee J, Kim S, Koo KT, Seol YJ, et al. Efficacy of sonic-powered toothbrushes for plaque removal in patients with peri-implant mucositis. J Periodontal Implant Sci. 2015; 45(2): 56-61. DOI: https://doi.org/10.5051/jpis.2015.45.2.56

Riben-Grundstrom C, Norderyd O, André U, Renvert S. Treatment of peri-implant mucositis using a glycine powder air-polishing or ultrasonic device: a randomized clinical trial. J Clin Periodontol. 2015; 42(5): 462-9. DOI: https://doi.org/10.1111/jcpe.12395

Faggion CM, Chambrone L, Listl S, Tu YK. Network meta-analysis for evaluating interventions in implant dentistry: the case of peri-implantitis treatment. Clin Implant Dent Relat Res. 2013; 15(4): 576-88. DOI: https://doi.org/10.1111/j.1708-8208.2011.00384.x

Renvert S, Samuelsson E, Lindahl C, Persson GR. Mechanical non-surgical treatment of peri-implantitis: a double-blind randomized longitudinal clinical study. I: clinical results. J Clin Periodontol. 2009; 36(7): 604-9. DOI: https://doi.org/10.1111/j.1600-051X.2009.01421.x

Schwarz F, Sculean A, Rothamel D, Schwenzer K, Georg T, Becker J. Clinical evaluation of an Er: YAG laser for nonsurgical treatment of peri-implantitis: a pilot study. Clin Oral Implants Res. 2005; 16(1): 44-52. DOI: https://doi.org/10.1111/j.1600-0501.2004.01051.x

Sahm N, Becker J, Santel T, Schwarz F. Non-surgical treatment of peri-implantitis using an air-abrasive device or mechanical debridement and local application of chlorhexidine: a prospective, randomized, controlled clinical study. J Clin Periodontol. 2011; 38(9): 872-8. DOI: https://doi.org/10.1111/j.1600-051X.2011.01762.x

Klinge B, Gustafsson A, Berglundh T. A systematic review of the effect of anti-infective therapy in the treatment of peri-implantitis. J Clin Periodontol. 2002; 29(Suppl 3): 213-33.

Kotsovilis S, Karoussis IK, Trianti M, Fourmousis I. Therapy of peri-implantitis: a systematic review. J Clin Periodontol. 2008; 35(7): 621-9. DOI: https://doi.org/10.1111¿/j.1600-051X.2008.01240.x

Esposito M, Grusovin MG, Worthington HV. Treatment of peri-implantitis: what interventions are effective? A Cochrane systematic review. Eur J Oral Implantol. 2012; 5Suppl: S21-41.

Lin GH, Chan HL, Wang HL. The significance of keratinized mucosa on implant health: a systematic review. J Periodontol. 2013; 84(12): 1755-67. DOI: https://doi.org/10.1902/jop.2013.120688

Esposito M, Grusovin MG, Coulthard P, Worthington HV. The efficacy of interventions to treat periimplantitis: a Cochrane systematic review of randomised controlled clinical trials. Eur J Oral Implantol. 2008; 1(2): 111-25.

Karring ES, Stavropoulos A, Ellegaard B, Karring T. Treatment of peri-implantitis by the Vector system. Clin Oral Implants Res. 2005; 16(3): 288-93. DOI: https://doi.org/10.1111/j.1600-0501.2005.01141.x

Deppe H, Horch H-H, Neff A. Conventional versus CO2 laser-assisted treatment of peri-implant defects with the concomitant use of pure-phase beta-tricalcium phosphate: a 5-year clinical report. Int J Oral Maxillofac Implants. 2007; 22(1): 79-86.

Renvert S, Lindahl C, Roos Jansåker A-M, Persson GR. Treatment of peri-implantitis using an Er:YAG laser or an air-abrasive device: a randomized clinical trial. J Clin Periodontol. 2011; 38(1): 65-73. DOI: https://doi.org/10.1111/j.1600-051X.2010.01646.x

Schär D, Ramseier CA, Eick S, Arweiler NB, Sculean A, Salvi GE. Anti-infective therapy of peri-implantitis

with adjunctive local drug delivery or photodynamic therapy: six-month outcomes of a prospective randomized clinical trial. Clin Oral Implants Res. 2013; 24(1): 104-10. DOI: https://doi.org/10.1111/j.1600-0501.2012.02494.x

Bassetti M, Schär D, Wicki B, Eick S, Ramseier CA, Arweiler NB, et al. Anti-infective therapy of periimplantitis with adjunctive local drug delivery or photodynamic therapy: 12-month outcomes of a randomized controlled clinical trial. Clin Oral Implants Res. 2014; 25(3): 279-87. DOI: https://doi.


Kotsakis GA, Konstantinidis I, Karoussis IK, Ma X, Chu H. Systematic review and meta-analysis of the effect of various laser wavelengths in the treatment of peri-implantitis. J Periodontol. 2014; 85(9): 1203-13. DOI: https://doi.org/10.1902/jop.2014.130610

Romanos GE, Javed F. Laser Therapy is Safe but not Superior to Conventional Treatment of Peri-implantitis. J Evid-Based Dent Pract. 2015; 15(2): 55-7. DOI: https://doi.org/10.1016/j.jebdp.2015.03.005

Schwarz F, John G, Mainusch S, Sahm N, Becker J. Combined surgical therapy of peri-implantitis evaluating

two methods of surface debridement and decontamination. A two-year clinical follow up report. J Clin Periodontol. 2012; 39(8): 789-97. DOI: https://doi.org/10.1111/j.1600-051X.2012.01867.x

Schwarz F, Hegewald A, John G, Sahm N, Becker J. Four-year follow-up of combined surgical therapy of advanced peri-implantitis evaluating two methods of surface decontamination. J Clin Periodontol. 2013; 40(10): 962-7. DOI: https://doi.org/10.1111/jcpe.12143

Louropoulou A, Slot DE, Van der Weijden FA. Titanium surface alterations following the use of different mechanical instruments: a systematic review. Clin Oral Implants Res. 2012; 23(6): 643-58. DOI: https://doi.org/10.1111/j.1600-0501.2011.02208.x

Renvert S, Lindahl C, Roos Jansåker A-M, Persson GR. Treatment of peri-implantitis using an Er:YAG laser or an air-abrasive device: a randomized clinical trial. J Clin Periodontol. 2011; 38(1): 65-73. DOI: https://doi.org/10.1111/j.1600-051X.2010.01646.x

Ronay V, Merlini A, Attin T, Schmidlin PR, Sahrmann P. In vitro cleaning potential of three implant debridement methods. Simulation of the non-surgical approach. Clin Oral Implants Res. 2017; 28(2): 151-5. DOI: https://doi.org/10.1111/clr.12773

Bassetti M, Bassetti R, Sculean A, Salvi GE. [Subcutaneous emphysema following non-surgical periimplantitis therapy using an air abrasive device: a case report]. Swiss Dent J. 2014; 124(7-8): 807-17

Naenni N, Schneider D, Jung RE, Hüsler J, Hämmerle CHF, Thoma DS. Randomized clinical study assessing two membranes for guided bone regeneration of peri-implant bone defects: clinical and histological outcomes at 6 months. Clin Oral Implants Res. 2017; 28(10): 1309-17. DOI: https://doi.org/10.1111/clr.12977

Ramanauskaite A, Daugela P, Juodzbalys G. Treatment of peri-implantitis: Meta-analysis of findings in a systematic literature review and novel protocol proposal. Quintessence Int. 2017; 47(5): 379-93. DOI: https://doi.org/10.3290/j.qi.a35131

Aghazadeh A, Rutger Persson G, Renvert S. A single-center randomized controlled clinical trial on the adjunct treatment of intra-bony defects with autogenous bone or a xenograft: results after 12 months. J Clin Periodontol. 2012; 39(7): 666-73. DOI: https://doi.org/10.1111/j.1600-051X.2012.01880.x

Wohlfahrt JC, Lyngstadaas SP, Rønold HJ, Saxegaard E, Ellingsen JE, Karlsson S, et al. Porous titanium granules in the surgical treatment of peri-implant osseous defects: a randomized clinical trial. Int J Oral Maxillofac Implants. 2012; 27(2): 401-10.

Jepsen K, Jepsen S, Laine ML, Anssari Moin D, Pilloni A, Zeza B, et al. Reconstruction of Peri-implant Osseous Defects: A Multicenter Randomized Trial. J Dent Res. 2016; 95(1): 58-66. DOI: https://doi.org/10.1177/0022034515610056

Khoury F, Buchmann R. Surgical therapy of peri-implant disease: a 3-year follow-up study of cases treated with 3 different techniques of bone regeneration. J Periodontol. 2001; 72(11): 1498-508. DOI: https://doi.org/10.1902/jop.2001.72.11.1498

Froum SJ, Froum SH, Rosen PS. Successful management of peri-implantitis with a regenerative approach: a consecutive series of 51 treated implants with 3- to 7.5-year follow-up. Int J Periodontics Restorative Dent. 2012; 32(1): 11-20

Schwarz F, Sahm N, Bieling K, Becker J. Surgical regenerative treatment of peri-implantitis lesions using

a nanocrystalline hydroxyapatite or a natural bone mineral in combination with a collagen membrane: a four-year clinical follow-up report. J Clin Periodontol. 2009; 36(9): 807-14. DOI: https://doi.org/10.1111/j.1600-051X.2009.01443.x

Schwarz F, Bieling K, Latz T, Nuesry E, Becker J. Healing of intrabony peri-implantitis defects following application of a nanocrystalline hydroxyapatite (Ostim) or a bovine-derived xenograft (Bio-Oss) in combination with a collagen membrane (Bio-Gide). A case series. J Clin Periodontol. 2006; 33(7): 491-9. DOI: https://doi.org/10.1111/j.1600-051X.2006.00936.x

Schwarz F, Sculean A, Bieling K, Ferrari D, Rothamel D, Becker J. Two-year clinical results following treatment

of peri-implantitis lesions using a nanocrystalline hydroxyapatite or a natural bone mineral in combination

with a collagen membrane. J Clin Periodontol. 2008; 35(1): 80-7. DOI: https://doi.org/10.1111/j.1600-051X.2007.01168.x

Hallström H, Lindgren S, Widén C, Renvert S, Twetman S. Probiotic supplements and debridement of periimplant mucositis: a randomized controlled trial. Acta Odontol Scand. 2016; 74(1): 60-6. DOI: https://doi.org/10.3109/00016357.2015.1040065

Ramberg P, Lindhe J, Botticelli D, Botticelli A. The effect of a triclosan dentifrice on mucositis in subjects with dental implants: a six-month clinical study. J Clin Dent. 2009; 20(3): 103-7.

DOI: https://doi.org/10.17533/udea.rfo.v31n1-2a1 Abstract : 473 PDF : 68

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Comments on this article

View all comments

Esta publicación hace parte del Sistema de Revistas de la Universidad de Antioquia
¿Quieres aprender a usar el Open Journal system? Ingresa al Curso virtual
Este sistema es administrado por el Programa Integración de Tecnologías a la Docencia
Universidad de Antioquia
Powered by Public Knowledge Project